- RESEARCH USE ONLY
- INDEPENDENTLY THIRD-PARTY TESTED
- COA EVERY LOT
- US-BASED OPERATIONS
| Specification | Details |
|---|---|
| Compound | SS-31 (Elamipretide) |
| Type | Synthetic mitochondria-targeted tetrapeptide |
| Sequence | D-Arg-2,6-dimethyl-Tyr-Lys-Phe-NH₂ |
| Quantity | 10 mg |
| Purity | ≥99% HPLC Certified |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Molecular Formula | C₃₂H₄₉N₉O₅ |
| Molecular Weight | 639.8 g/mol |
| CAS Number | 736992-21-5 |
| Solubility | Soluble in laboratory-grade sterile water |
| Documentation | COA included in product image gallery |
$450.00
For Research Use Only | Not for Human or Veterinary Use
SS-31, also known as elamipretide, is a synthetic mitochondria-targeted tetrapeptide studied for its interactions with mitochondrial membranes and the phospholipid cardiolipin. Research has examined how SS-31 associates with the inner mitochondrial membrane and influences membrane properties, cardiolipin interactions, and mitochondrial bioenergetics.
This research material is supplied as a lyophilized powder for laboratory research, analytical testing, and related scientific applications.
The molecular identity above corresponds to elamipretide as listed by PubChem. Elamipretide hydrochloride is a separate salt form, so the exact salt designation should be confirmed against the batch COA where applicable.
SS-31 belongs to the Szeto-Schiller peptide class. Its structure contains alternating cationic and aromatic residues, a feature associated with its ability to interact with negatively charged mitochondrial membranes. Research has particularly focused on its interaction with cardiolipin, a phospholipid enriched in the inner mitochondrial membrane.
Cardiolipin has an important structural role in mitochondrial inner membranes and is closely associated with proteins involved in oxidative phosphorylation. Experimental studies have shown that SS-31 selectively interacts with cardiolipin-containing membranes and can alter membrane surface electrostatics and lipid packing.
Research has also investigated SS-31 in relation to cardiolipin-associated proteins, including cytochrome c and components involved in mitochondrial energy metabolism. These studies help characterize the molecular interactions of the peptide rather than establishing general clinical effects.
Studies of SS-31 have examined mitochondrial respiration, membrane structure, ATP-related processes, and interactions with proteins involved in mitochondrial bioenergetics. More recent research has also investigated its interaction with the adenine nucleotide translocator and its relationship with mitochondrial ADP sensitivity.
The available literature includes biophysical, cellular, animal, and clinical research, but findings from experimental models should not be presented as established effects of research-grade SS-31 in humans.
SS-31 is the research designation commonly associated with elamipretide, which has also appeared in the literature under names including MTP-131 and Bendavia. PubChem identifies elamipretide as a synthetic tetrapeptide with the sequence D-Arg-2,6-dimethyl-L-Tyr-L-Lys-L-Phe-NH₂.
| Research Identity | Description |
|---|---|
| SS-31 | Common research designation |
| Elamipretide | Established name for the compound |
| MTP-131 | Development/research designation |
| Bendavia | Historical development name |
The regulatory status of elamipretide has changed. On September 19, 2025, the U.S. FDA granted accelerated approval to Forzinity (elamipretide) for improving muscle strength in adults and pediatric patients with Barth syndrome who weigh at least 30 kg.
That approval applies to the specific FDA-approved pharmaceutical product and its labeled indication. It does not mean that research-grade SS-31 material is an approved drug or that this product carries the formulation, manufacturing controls, labeling, or approved-use status of Forzinity.
Each product is supplied with documentation intended to support laboratory identification and quality review. The product listing specifies ≥99% HPLC-certified purity, with the COA available through the product image gallery.
Researchers should use the batch-specific COA as the primary reference for identity, purity, and other analytical parameters associated with the supplied material.
SS-31 is a synthetic mitochondria-targeted tetrapeptide also known as elamipretide. Research has focused on its interactions with mitochondrial membranes and cardiolipin.
The reported sequence is D-Arg-2,6-dimethyl-Tyr-Lys-Phe-NH₂. It contains a D-arginine residue and a 2,6-dimethylated tyrosine residue.
A major focus of SS-31 research is its interaction with cardiolipin, an anionic phospholipid concentrated in the inner mitochondrial membrane.
Yes. SS-31 is commonly used as a research designation for elamipretide. The compound has also been identified in research and development records as MTP-131 and Bendavia.
The molecular weight of elamipretide is listed by PubChem as approximately 639.8 g/mol for the molecular form represented by formula C₃₂H₄₉N₉O₅. Salt forms can have different molecular weights.
Elamipretide was granted accelerated FDA approval in 2025 as Forzinity for a specific Barth syndrome indication. This approval applies to the approved pharmaceutical product and does not make research-grade SS-31 an FDA-approved product.
SS31 | The 10-Pack is supplied as a laboratory research material with ≥99% HPLC-certified purity and batch documentation available through the product gallery.
For Research Use Only | Not for Human or Veterinary Use
This material is intended strictly for laboratory research, analytical, and scientific applications. It is not intended for human or veterinary administration, diagnostic use, or therapeutic use.
