For Research Use Only | Not for Human or Veterinary Use

Description

Kisspeptin is a family of neuropeptides encoded by the KISS1 gene and studied for its interaction with the kisspeptin receptor, KISS1R. Kisspeptin-KISS1R signaling is closely connected with research into gonadotropin-releasing hormone (GnRH) neuronal activity and reproductive neuroendocrinology.

This research material is supplied as a lyophilized powder for laboratory research, analytical testing, and related scientific applications.

Note: Kisspeptin exists in several peptide forms, including kisspeptin-10, kisspeptin-14, kisspeptin-28, and kisspeptin-54. These forms have different molecular structures and molecular weights. The exact sequence and chemical specifications should therefore be confirmed from the batch-specific COA before assigning molecular formula, molecular weight, or CAS information to this material.

Research & Scientific Context

Kisspeptins are endogenous signaling peptides derived from the KISS1 gene. Their biological activity is mediated primarily through the G protein-coupled receptor KISS1R, also known as GPR54. Research has established the kisspeptin-KISS1R system as an important signaling pathway in studies of GnRH neuronal function.

Different kisspeptin fragments have been used in experimental research. For example, human kisspeptin-10 is a 10-amino-acid peptide, while kisspeptin-14 and kisspeptin-54 represent longer peptide forms. Their sequences and molecular properties are distinct, which is why the specific research material should be identified before interpreting analytical data.

Key Research Areas

Kisspeptin-KISS1R receptor signaling

GnRH neuronal research

Neuroendocrine signaling

Peptide-receptor interactions

Reproductive neuroendocrinology

Structure and function of kisspeptin peptide variants

Kisspeptin Variants

Peptide form	General description
Kisspeptin-10	Short C-terminal kisspeptin fragment; 10 amino acids
Kisspeptin-14	14-amino-acid human kisspeptin fragment
Kisspeptin-28	Longer kisspeptin peptide fragment
Kisspeptin-54	Longer human kisspeptin form; also associated with the metastin sequence

These are chemically distinct peptides rather than interchangeable names for one molecular structure.

Analytical Documentation

A Certificate of Analysis (COA) is included in the product image gallery. Researchers should use the batch-specific documentation to confirm the exact kisspeptin form, sequence, purity, and other analytical characteristics before using the material in laboratory work.

This distinction is particularly important for kisspeptin because multiple peptide lengths are commercially and scientifically referenced under the broader kisspeptin name.

Frequently Asked Questions

1. What is kisspeptin?

Kisspeptin refers to a group of peptides encoded by the KISS1 gene. These peptides interact with KISS1R and are widely studied in neuroendocrine signaling research.

2. Is kisspeptin the same as kisspeptin-10?

Not necessarily. Kisspeptin-10 is one specific peptide form within the broader kisspeptin family. Other forms, including kisspeptin-14, -28, and -54, have different sequences.

3. What is KISS1R?

KISS1R is the receptor through which kisspeptin signaling is primarily mediated. It is also known as GPR54 and is studied in connection with GnRH neuronal signaling.

4. Why are there different kisspeptin peptide lengths?

Kisspeptin peptides can exist as different processed fragments derived from the KISS1 precursor. Research materials may therefore represent different peptide lengths with distinct sequences and molecular properties.

5. What should be confirmed on the COA?

The COA should be checked for the exact peptide identity, sequence or peptide form, reported purity, batch information, and other available analytical results.

6. Does kisspeptin have one molecular weight?

No. Molecular weight depends on the specific kisspeptin form. For example, PubChem reports approximately 1,302.4 g/mol for human kisspeptin-10 and 3,229.6 g/mol for human kisspeptin-54 (27–54).

Research Materials & Documentation

KISSPEPTIN is supplied as a 5 mg lyophilized research material with ≥99% HPLC-certified purity. Batch documentation is available through the product image gallery for laboratory review.

Researchers should confirm the exact kisspeptin variant against the accompanying COA before using molecular specifications or analytical identifiers in research records.

For Research Use Only | Not for Human or Veterinary Use.