For Research Use Only | Not for Human or Veterinary Use

Description

PT-141, also known as bremelanotide, is a synthetic cyclic heptapeptide and melanocortin receptor agonist. It was developed as an analogue of α-melanocyte-stimulating hormone (α-MSH) and has been investigated in pharmacology and melanocortin receptor research.

This research material is supplied as a lyophilized powder for laboratory research, analytical testing, and related scientific applications.

The molecular formula, molecular weight, CAS number, and peptide sequence correspond to the bremelanotide free-base entry documented by PubChem. Bremelanotide acetate is a separate salt form with different reported molecular composition and molecular weight, so the exact batch form should be confirmed against the accompanying COA.

Research & Scientific Context

PT-141 was developed from the melanocortin peptide pathway and is structurally related to α-MSH. Research has examined its interaction with melanocortin receptors, particularly MC3R and MC4R, making it relevant to studies of melanocortin signaling and receptor pharmacology.

Its cyclic structure results from a lactam bridge within the peptide. The sequence also contains D-phenylalanine and N-terminal acetylation, features that distinguish bremelanotide from naturally occurring α-MSH.

Key Research Characteristics

Synthetic cyclic heptapeptide

Analogue of α-MSH

Melanocortin receptor agonist

Studied in MC3R and MC4R research

Contains a lactam-linked cyclic peptide structure

Documented in both preclinical and human clinical research

Regulatory & Research Status

Bremelanotide has a documented regulatory history in the United States. The FDA approved Vyleesi (bremelanotide injection) in 2019 for a specific indication in premenopausal women with acquired, generalized hypoactive sexual desire disorder. The approved product is a defined pharmaceutical formulation supplied as a subcutaneous injection.

This regulatory approval should not be interpreted as approval of research-grade PT-141 materials or this lyophilized research presentation. The FDA-approved product and its labeling specify a particular formulation, strength, delivery system, and intended clinical use.

Analytical Documentation

A Certificate of Analysis (COA) is included in the product image gallery. Researchers should use the batch-specific documentation to verify reported purity and other analytical characteristics before incorporating a material into laboratory workflows.

Because salt forms can have different molecular compositions, researchers should also use the COA and supplier documentation to confirm the exact chemical form of an individual batch.

Frequently Asked Questions

1. What is PT-141?

PT-141 is the research code commonly associated with bremelanotide, a synthetic cyclic heptapeptide and melanocortin receptor agonist.

2. Is PT-141 the same compound as bremelanotide?

Yes. PT-141 is an established synonym for bremelanotide. FDA substance records also identify PT-141 with bremelanotide.

3. What receptors are studied with PT-141?

Bremelanotide has been investigated as a melanocortin receptor agonist, including activity involving MC3R and MC4R.

4. What is the molecular weight of PT-141?

The reported molecular weight of bremelanotide free base is approximately 1025.2 g/mol. The molecular weight differs for acetate salt forms.

5. Does PT-141 have an FDA-approved product?

Yes. The FDA approved Vyleesi, a specific bremelanotide injection formulation, in 2019. That approval applies to the specified pharmaceutical product and indication, not to research-grade PT-141 materials generally.

6. What should researchers check before using a PT-141 research material?

Researchers should review the batch-specific COA, confirm the chemical form and reported purity, and ensure the material is appropriate for the intended laboratory or analytical application.

Research Materials & Documentation

PT-141 Spray is supplied as a 10 mg lyophilized research material with ≥99% HPLC-certified purity. Batch documentation is provided through the product image gallery for laboratory review.

For Research Use Only | Not for Human or Veterinary Use.