For Research Use Only | Not for Human or Veterinary Use

Description

5-Amino-1MQ is a small-molecule quinolinium compound studied in laboratory research as an inhibitor of nicotinamide N-methyltransferase (NNMT). Unlike peptide research materials, 5-Amino-1MQ contains no amino-acid sequence or peptide bonds.

Published research has examined NNMT inhibition and its relationship to cellular methylation and nicotinamide metabolism. Experimental findings include cell-based and animal-model research, so these results should be interpreted within their specific research settings rather than as established human outcomes.

This material is supplied as a lyophilized powder for laboratory research, analytical testing, and related scientific applications.

Important identity note: 5-Amino-1MQ appears in chemical databases in different forms, including the quinolinium cation and iodide salt. The cation is listed as C₁₀H₁₁N₂⁺ with a molecular weight of 159.21 g/mol, while the iodide salt is C₁₀H₁₁IN₂ with a molecular weight of approximately 286.12 g/mol and CAS 42464-96-0. The applicable molecular specification should therefore match the exact form documented on the batch COA.

Research & Scientific Context

5-Amino-1MQ has been investigated as a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that transfers a methyl group from S-adenosylmethionine to nicotinamide. This reaction connects NNMT activity with nicotinamide metabolism, methyl-donor availability, and related cellular metabolic pathways.

Research has examined 5-Amino-1MQ in cellular and animal models. A recent study, for example, evaluated the compound in diet-induced obese mice while measuring metabolic variables, tissue distribution, and pharmacokinetic parameters. These findings represent experimental animal research and should not be presented as evidence of established effects in humans.

Because 5-Amino-1MQ is a small molecule rather than a peptide, its analytical characterization is based on chemical identity, molecular structure, chromatographic purity, and related analytical measurements rather than peptide sequence verification.

Analytical Documentation

The supplied material is specified at ≥99% HPLC Certified purity, with a Certificate of Analysis included in the product image gallery.

Researchers should review the batch-specific COA for the exact chemical form, analytical method, purity result, and other reported specifications before incorporating the material into laboratory workflows.

Research Status

5-Amino-1MQ remains an experimental research compound. Published work has primarily involved biochemical, cellular, and animal research, including investigations into NNMT inhibition and metabolic pathways.

The material supplied here is intended strictly for laboratory research and analytical applications and is not represented as an approved pharmaceutical, therapeutic, diagnostic, or veterinary product.

Frequently Asked Questions

1. Is 5-Amino-1MQ a peptide?

No. 5-Amino-1MQ is a small-molecule quinolinium compound, not a peptide. It contains no amino-acid sequence or peptide bonds.

2. What enzyme is 5-Amino-1MQ studied against?

5-Amino-1MQ has been studied as an inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT catalyzes the methylation of nicotinamide using S-adenosylmethionine as the methyl donor.

3. What does NNMT do?

NNMT is an enzyme involved in nicotinamide metabolism. It uses S-adenosylmethionine to methylate nicotinamide, linking its activity with cellular methylation chemistry and the handling of nicotinamide.

4. Does 5-Amino-1MQ have an amino acid sequence?

No. Since 5-Amino-1MQ is a small molecule rather than a peptide, it does not have an amino acid sequence. Its identity is instead described through its chemical structure and molecular identifiers.

5. Why are different molecular weights reported for 5-Amino-1MQ?

Different values can refer to different chemical forms. The quinolinium cation is listed at approximately 159.21 g/mol, while the iodide salt is approximately 286.12 g/mol. The exact value should be taken from the chemical form specified on the applicable COA.

6. What types of research have studied 5-Amino-1MQ?

Research has included biochemical and cellular studies of NNMT inhibition as well as animal-model research examining metabolic and pharmacokinetic parameters. The available findings are experimental and should be interpreted according to the model and study design used.

Research Materials & Documentation

5-Amino-1MQ is supplied as a laboratory research material with HPLC-certified purity and batch documentation available through the product gallery.

For Research Use Only | Not for Human or Veterinary Use