- RESEARCH USE ONLY
- INDEPENDENTLY THIRD-PARTY TESTED
- COA EVERY LOT
- US-BASED OPERATIONS
| Specification | Details |
|---|---|
| Compound | SS31 |
| Alternative Names | Elamipretide / MTP-131 |
| Type | Synthetic mitochondria-targeting tetrapeptide |
| Sequence | D-Arg-Dmt-Lys-Phe-NH₂ |
| Quantity | 10 mg |
| Purity | ≥99% HPLC Certified |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Solubility | Soluble in laboratory-grade sterile water |
| Documentation | Certificate of Analysis supplied with the applicable batch |
$64.99
For Research Use Only | Not for Human or Veterinary Use
SS31, also known as elamipretide or MTP-131, is a synthetic mitochondria-targeting tetrapeptide investigated in laboratory research involving mitochondrial membranes and bioenergetics. Its sequence is D-Arg-Dmt-Lys-Phe-NH₂, where Dmt refers to 2′,6′-dimethyltyrosine. Research has identified cardiolipin, a distinctive phospholipid of the inner mitochondrial membrane, as an important molecular interaction site for SS31.
SS31 has been examined in biochemical, cellular, and animal research models to investigate mitochondrial membrane properties, cardiolipin interactions, electron transport, and cellular bioenergetics. These findings describe experimental mechanisms and model-specific observations rather than established human or veterinary applications.
SS31 belongs to the Szeto-Schiller (SS) family of mitochondria-targeting peptides. Its molecular design combines positively charged residues with aromatic residues, allowing the peptide to interact with negatively charged mitochondrial membrane components.
A central research feature of SS31 is its ability to associate with the inner mitochondrial membrane. Experimental studies indicate that its mitochondrial localization is strongly associated with interactions involving cardiolipin rather than simply relying on membrane potential-driven accumulation.
This property has made SS31 useful for laboratory studies examining how a small synthetic peptide can interact with mitochondrial membrane lipids and influence membrane-associated processes.
Cardiolipin is a specialized phospholipid concentrated within the inner mitochondrial membrane. It contributes to mitochondrial membrane organization, cristae structure, and the function of protein complexes involved in oxidative phosphorylation.
Experimental work has shown that SS31 interacts with cardiolipin-containing membranes and can alter their surface electrostatics and lipid-packing properties. These observations have helped refine understanding of how SS31 interacts with mitochondrial membranes at the molecular level.
SS31 has also been investigated in experimental systems involving electron transport and ATP synthesis. In biochemical and mitochondrial preparations, research has examined whether SS31–cardiolipin interactions influence cytochrome c function and mitochondrial respiration.
More recent mechanistic research suggests that the effects of SS31 extend beyond a simple antioxidant model. Studies have investigated its influence on mitochondrial membrane electrostatics, cardiolipin-dependent protein interactions, respiratory-chain organization, and overall mitochondrial bioenergetics.
One area of interest is the relationship between SS31 and cardiolipin-associated protein complexes. Protein-interaction studies have identified SS31-associated mitochondrial proteins involved in oxidative phosphorylation and metabolic processes, with many of these proteins also known to interact with cardiolipin.
This makes SS31 a useful experimental compound for studying the connection between mitochondrial membrane lipids, protein organization, and bioenergetic processes.
SS31 is supplied as a lyophilized research material with ≥99% HPLC-certified purity.
A Certificate of Analysis (COA) is included with the applicable product documentation. Researchers should refer to the batch-specific COA when evaluating the material's reported analytical characteristics.
Quantity: 10 mg
Form: Lyophilized powder
Appearance: White to off-white powder
Purity: ≥99% HPLC Certified
Solubility: Soluble in laboratory-grade sterile water
COA: Included with product documentation
Intended Use: Laboratory research only
SS31 is the designation commonly used for elamipretide, a member of the Szeto-Schiller family of mitochondria-targeting tetrapeptides. It is also known as MTP-131.
SS31 has the sequence D-Arg-Dmt-Lys-Phe-NH₂. Dmt is 2′,6′-dimethyltyrosine, a modified aromatic amino acid incorporated into the peptide structure.
Cardiolipin is a specialized phospholipid concentrated in the inner mitochondrial membrane. It contributes to membrane architecture and interacts with several proteins involved in mitochondrial energy metabolism.
Experimental studies indicate that SS31 associates with cardiolipin-containing membranes through electrostatic and other molecular interactions. Research has also shown effects on membrane surface electrostatics and lipid packing.
Yes. Experimental work has examined SS31 using isolated mitochondria, mitoplasts, model lipid membranes, and other biochemical systems to investigate cardiolipin interactions, respiration, and cytochrome c function.
Yes. SS31, elamipretide, and MTP-131 are names used for the same synthetic mitochondria-targeting tetrapeptide. Research literature may use any of these designations depending on the study or development stage.
Review the SS31 scientific specifications and applicable Certificate of Analysis when evaluating this material for laboratory research. SS31 is supplied strictly as a research material and is not intended for human or veterinary use.
